What is the antidote for Aspirin (ASA) overdose?

The correct antidote for aspirin (ASA) overdose is sodium bicarbonate, which is commonly used to help alkalinize the urine. This facilitates the renal excretion of salicylates, such as those found in aspirin. As salicylate levels rise, significant metabolic acidosis can occur, and bicarbonate administration helps to correct this imbalance.

Bicarbonate works by increasing blood pH, which enhances the ionization of salicylate in the renal tubules, thereby promoting its elimination through urination. This is a critical therapeutic approach to managing aspirin overdose, as it reduces the potential for toxicity and adverse events associated with high salicylate levels, such as gastrointestinal bleeding and central nervous system effects.

The other options presented do not serve as antidotes for aspirin overdose. Understanding the specific role of bicarbonate in treating salicylate toxicity is essential for effectively managing such cases.