What is the appropriate antidote for cocaine overdose?

In cases of cocaine overdose, benzodiazepines are the appropriate choice for management. Cocaine can lead to significant agitation, hypertension, and cardiovascular complications due to its stimulatory effects on the central nervous system. Benzodiazepines serve multiple purposes in this scenario. They help reduce anxiety and agitation, which can be particularly severe in these patients. Additionally, benzodiazepines can aid in controlling seizures and provide sedation, thereby mitigating some of the life-threatening reactions associated with cocaine overdose.

Furthermore, they have a role in managing the autonomic instability caused by cocaine toxicity, such as elevated heart rate and blood pressure. This makes benzodiazepines not only a useful adjunct for symptom management but also a safer alternative compared to other potential treatments that may exacerbate the situation.

The other options listed, although important in different contexts, do not serve as suitable antidotes for cocaine overdose specifically.