What is the typical maintenance dose of Vecuronium after the initial administration?

The typical maintenance dose of Vecuronium after the initial administration is generally in the range of 0.01-0.015 mg/kg. This dosing is established based on the pharmacodynamics of neuromuscular blocking agents. After the initial bolus, which induces neuromuscular blockade, the maintenance dose is tailored to sustain the desired level of muscle relaxation while minimizing potential side effects and duration of action.

Using this lower range helps ensure that patients do not experience excessive neuromuscular blockade, which can lead to complications such as respiratory depression or prolonged paralysis upon discontinuation of the drug. The maintenance doses can vary depending on factors such as the clinical scenario, duration of surgery, and individual patient responses.

The recommended maintenance range effectively balances the need for ongoing neuromuscular block with patient safety and is important for managing sedation in procedures where endotracheal intubation is necessary, or when muscle relaxation is needed.